• 1.Dr. Bakaletz says this study provides evidence for a new treatment regimen to target biofilms formed by NTHI during middle ear infection. One approach would be to deliver a therapeutic agent that can disrupt bacterial DNA, in conjunction with human beta-defensin-3 to the middle ear of a child with chronic, recurrent infection. Physicians could follow the same pathway used to target the middle ear during ear tube surgery, a common treatment for chronic ear infections.


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  • 2.Investigators in The Research Institute at Nationwide Children's Hospital hypothesized that human beta-defensin-3 might lose its power to kill NTHI if it got caught up within the extracellular DNA that makes up a biofilm's outer layer, thus preventing its contact with bacteria within the biofilm.


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  • 3.Researchers at the University of Cincinnati (UC, OH, USA) carried out a laboratory study in which they created genetically altered surface skin cells (keratinocytes) from donated tissue samples, giving them enhanced infection-fighting abilities. These cells were then infected with the bacteria Pseudomonas aeruginosa, commonly found in hospitals, and allowed to incubate. Later analysis revealed that the genetically altered cells--modified to produce higher levels of a protein known as human beta defensin 4 (HBD4)--were more resistant to microbial infections than the unaltered cells.

    辛辛那提大学研究员完成了这项研究,他们从捐赠的组织样本中创造性的改变了表面皮肤细胞的遗传基因(角质化细胞),提高了抗感染能力。在医院中常发生细胞被假单胞菌铜绿菌素的细菌所感染或潜伏的情况。 之后分析显示遗传基因被改变的细胞——对常见的蛋白质βdefensin4(HBD4)进行改良使达到更高水平——改变后的细胞较未改变的对细菌抵抗力有很大提高

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