degrade

英[dɪˈɡreɪd ] 美[dɪˈɡreɪd ]

[ 原形: degrade 现在分词: degrading 过去分词: degraded 第三人称: degrades ]


丁香医学词典

 

降低,递降,减低,退化

简明英汉

 

v. (使)降级,(使)堕落,(使)退化

论文例句

 
  • 1.The researchers identified different methods to enhance CNT1 function and slow growth of the tumor cells. They found that by using additional drugs that inhibit pathways that degrade CNT1, they could partially restore its normal function and transport more gemcitabine into the tumor cells to prevent proliferation of the tumor.

    研究人员发现了多种不同的促进CNT1功能和减缓肿瘤细胞生长速度的方法。他们发现,添加药物对CNT1降解的通路进行抑制,可以部分恢复这种蛋白的正常功能,让更多的吉西他滨进入肿瘤细胞从而抑制肿瘤细胞的增殖。

    来自 论坛

  • 2.The UCSF's analyses also identified a physical interaction between the HIVaccessory protein, Vif, and the transcription cofactor CBF-β, as part of itshijacking of a ubiquitin ligase complex that targets APOBEC3G for degradation. Additional RNA knockdownand genetic complementation studies reported in the team's second paperindicate that CBF-β is required for Vif-mediated degradation of APOBEC3G, and for preserving HIV-1 infectivity. Inthis paper, titled “Vif hijacks CBF-b to degrade APOBEC3G and promote HIV-1 infection,” the UCSFteam concludes that “methods of disrupting the CBF-β–Vif interaction mightenable HIV-1 restriction and provide a supplement to current antiviraltherapies that primarily target viral proteins.”

    加州大学旧金山分校的分析还发现了艾滋病毒辅助蛋白,VIF和转录辅助因子CBF -β之间的生化反应,作为其劫持一个目标APOBEC3G的降解的泛素连接酶复合的一部分。额外的RNA敲除和遗传互补研究发表在研究团队的第篇文章上,研究报告表明,CBF -β是Vif蛋白介导的降解APOBEC3G的需要,并为维护HIV-1感染性。在本文的标题为“Vif劫持CBF- B并降解APOBEC3G,促进HIV - 1感染”,加州大学旧金山分校的研究团队的结论是:“扰乱CBF -β- Vif的互动的方法可能使HIV-1受限制,为目前主要针对病毒蛋白的抗病毒治疗提供了一个补充”

    来自 论坛

  • 3.To distinguish between these possibilities, the researchers tested both Vpx as well as the related Vpr proteins from a panel representing all currently known primate lentiviruses for their ability to bind and degrade SAMHD1. When the phylogenetic history, or evolutionary relatedness, between these two viral proteins was mapped on top of their functions, the researchers found that SAMHD1-degrading ability was acquired first by the Vpr protein before the Vpx protein was even "born."

    为了区分这些可能性,研究人员测试了VPx以及一组代表所有目前已知灵长类慢病毒结合并降低SAMHD1蛋白表达相关的VPr蛋白。当这两种病毒蛋白功能之间进化相关性映射到进化历史上,研究人员发现,SAMHD1-VPr蛋白第一次获得降解能力早于VPx。甚至是“天生的”。

    来自 论坛

  • 4.The researchers also found that Vpr/Vpx proteins have highly species-specific abilities to degrade primate SAMHD1. Thus, while a lentivirus can degrade SAMHD1 within a single primate species, it cannot bind and degrade the SAMHD1 protein from a more distantly related species. The specificity of the virus for its particular host and the fact that SAMHD1 degradation was an evolutionary novelty among lentiviruses suggests that SAMHD1 from some primates is locked in an "evolutionary arms race" with Vpx/Vpr proteins.

    研究人员还发现,VPr/VPx蛋白具有高度物种特异性的能力能够降低灵长类动物SAMHD1。因此,在单一的灵长类动物体内,慢病毒可降解SAMHD1,但是不能在亲缘关系较远的物种体内连接和降低SAMHD1蛋白质。病毒对其特定宿主的特异性和慢病毒之间SAMHD1退化是一种新的进化的事实显示一些灵长类动物体内的SAMHD1被锁定在“进化军备竞赛”VPx/VPr蛋白质。

    来自 论坛

  • 5.not just let that motivation degrade in response to all the external demands we face,

    而不是在处理遇到的各种需求中降低运动积极性。

    来自 论坛

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